Pioneering a path forward

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We’re dedicated to transforming the lives of patients and their families living with hyperphagia and severe obesity caused by rare melanocortin-4 receptor (MC4R) pathway diseases by rapidly advancing care and precision medicines addressing the root cause.

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Learn about our translational research based on the largest known DNA database focused on obesity.

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Learn about our clinical development programs with trials in patients with rare obesities linked to variants in certain genes with strong or very strong relevance to the MC4R pathway.

Our news

2024-02-22T07:01:00

Rhythm Pharmaceuticals Announces Clinical Development Plan of Setmelanotide for Hypothalamic Obesity in Japan

2024-02-22T07:00:00

Rhythm Pharmaceuticals Reports Fourth Quarter 2023 Financial Results and Business Update

2024-02-08T16:01:00

Rhythm Pharmaceuticals Announces New Employment Inducement Grants

Dedicated to transforming the care of people living with rare genetic diseases of obesity

OUR COMMUNITY

We’re focused on the melanocortin-4 receptor (MC4R) pathway, which is responsible for regulating weight and hunger.


By targeting the MC4R pathway, we aim to develop therapeutics
for rare genetic diseases of obesity, including:

Proopiomelanocortin
(POMC) Deficiency Obesity
Leptin Receptor (LEPR)
Deficiency Obesity
Bardet-Biedl
Syndrome (BBS)
Alström
Syndrome
POMC or LEPR
Heterozygous Deficiency Obesity
Smith-Magenis
Syndrome
SRC1 Deficiency
Obesity
MC4R Deficiency
Obesity
SH2B1 Deficiency
Obesity
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